Peripheral nerve complications in patients infected with HIV usually result
from the virus itself, or are due to some of the antiretroviral drugs (zal
citabine, didanosine or stavudine), It may be difficult to distinguish betw
een these two aetiologies on clinical or neurophysiological criteria, Since
they are a significant cause of morbidity, a number of studies have looked
at agents used for symptomatic control. More recently, there has been a fo
cus on treatments that improve nerve function, including recombinant human
nerve growth factor and the reduction of HIV viral load with antiretroviral
drugs. Curr Opin Neurol 13:589-592. (C) 2000 Lippincott Williams & Wilkins
.