ESTROGEN-RECEPTOR VARIANTS AND MUTATIONS IN HUMAN BREAST-CANCER

Several oestrogen receptor variant and mutated mRNA species have been identified in human breast samples and cell lines. Over-expression and altered expression of some of these mRNAs have been correlated with b reast tumourigenesis and progression. The following review focuses on the current knowledge available in the scientific literature with resp ect to the type acid characteristics of oestrogen receptor variants an d mutations that have been identified as occurring naturally in human breast tissues and cell lines.