Treatment of rhinitis medicamentosa with fluticasone propionate - an experimental study

The efficacy of fluticasone propionate aqueous nasal spray (0.05% w/w) in t he treatment of rhinitis medicamentosa has been studied in an animal model (guinea pig) Rhinitis medicamentosa was induced through the instillation of 0.05% naphthazoline nitrate (Privine) for 8 weeks. Fluticasone propionate nasal spray was then administered to the animals for 2 weeks. The spray suc cessfully cleared the interstitial edema which is the pathologic hallmark o f rhinitis medicamentosa. The study suggests that fluticasone propionate na sal spray can be beneficial in the treatment of patients with rhinitis medi camentosa.