Comparison of outcome after pediatric liver transplantation for metabolic diseases and biliary atresia

Metabolic diseases (MD) are the second largest indication group for orthoto pic liver transplantation (OLTx) in children after biliary atresia (BA). A better outcome after transplantation can be expected because of a better pr etransplant condition and the absence of previous abdominal surgery. To pro ve this statement, patient survival, graft survival, and morbidity were com pared between a group of 24 for MD and 52 for BA consecutively transplanted children. The actuarial one- and five-year patient survival rates for MD w ere 96% and 84%, and for BA 84% and 70%, respectively (p logrank test = 0.1 7). Three MD children (13%) and 15 BA children (29%) died. The actuarial on e- and five-year graft survival rates for MD were 75% and 58%, and for BA 7 5% and 64%, respectively (p logrank test = 0.76). Seven MD children (29%) a nd 11 BA children (21%) were retransplanted. Postoperative bleeding and gas trointestinal complications occurred less frequent (4% vs. 18% and 4% vs. 1 4%, respectively), whereas biliary complications, viral infections, and acu te rejection occurred more frequently (38% vs. 21%, 29% vs. 15%, and 50% vs . 37%, respectively) in MD children. The difference in the incidence of the various postoperative complications between both groups was not statistica lly significant. The mean ICU and ventilator stay was 7.5 and four days, re spectively, in MD children and 16 and 10 days, respectively, in BA children (p = ns). The mean infection, complication, intervention, and retransplant ation rate was equal in both groups. Conclusion: Mortality and morbidity af ter pediatric liver transplantation for MD and BA are not different despite the better starting point for children with MD.