Concerning the syndromes in environmental medicine, like Multiple Chemical
Sensitivities (MCS), Idiopathic Environmental Intolerances (IEI), Sick Buil
ding Syndrome (SBS), Chronic Fatigue Syndrome (CFS), Candida Syndrome (CS),
and Burnout Syndrome (BS), scientific knowledge in etiology, pathology, pa
thophysiology, diagnosis, therapy, prevention and prognosis is still lackin
g until now. A critical comparison shows that it is still impossible to fin
d a scientifically satisfying delimitation. Syndromes in environmental medi
cine show clinical similarities to somatoform disorders. Furthermore, there
are the following possible explanations for the existence of these syndrom
es: Firstly, they may be a complex interaction of environmental impacts, in
dividual predispositions, psychological influences, as well as processes of
mental perception and interpretation. Secondly, they may be an effect of d
istress influenced by culture and social structures and/or thirdly, they ma
y be an iatrogenic determination. A more comprehensive characterisation whi
ch better considers the complex clinical manifestations is overdue. Althoug
h there are neither scientifically validated procedures for diagnosis or th
erapy nor prophylactic measures, a hardly comprehensible number of partly u
nvalidated methods is in practical use. Until the syndromes are not Finally
defined the terms for the syndromes should not be applied to a certain dis
ease. Despite all uncertainities in the evaluation of syndromes in environm
ental medicine, physicians have the duty to take the affected persons' prob
lems seriously.