We describe a case of relapsing acute pancreatitis apparently idiopathic in
a 55-year-old man. The patient did not smoke and was a modest and irregula
r drinker of wine. Endoscopic retrograde cholangiopancreatography showed an
initial dilatation of secondary ducts like a chronic pancreatitis of class
I of Cremer. Ultrasound and computed tomography resulted negative for panc
reatic lesions. In the follow-up however, magnetic resonance cholangiopancr
eatography detected the presence of an intraductal mucin-hypersecreting neo
plasm, a duct-ectatic mucinous cystic tumor of the pancreas, in the uncinat
e process. This is a benign lesion clearly recognized nowadays by magnetic
resonance cholangiopancreatography, because this radiological technique sho
ws the grape-like clusters of cystic lesions in secondary ducts communicati
ng with the main duct on the same plane. The radiological picture above exc
ludes a malignant lesion and a biopsy specimen is not required. Furthermore
, an intraductal mucin-hypersecreting neoplasm of the pancreas does not req
uire an immediate surgical resection because of its slow evolution and can
be followed-up. Conversely cystoadenocarcinoma spreads in peripheral ducts
and does not communicate with the Wirsung duct. It requires both surgical r
esection and a biopsy specimen for histological diagnosis. In the last epis
ode of acute pancreatitis, a sphincterotomy was performed at endoscopic ret
rograde cholangiopancreatography and our patient had no more pain for one y
ear.