Quantitative structure activity relationship (QSAR) studies of some substituted benzenesulphonyl glutamines as tumour suppressors

Authors
Srikanth, K Kumar, CA Goswami, D De, AU Jha, T
Citation
K. Srikanth et al., Quantitative structure activity relationship (QSAR) studies of some substituted benzenesulphonyl glutamines as tumour suppressors, I J BIOCH B, 38(1-2), 2001, pp. 120-123
Citations number
17
Categorie Soggetti
Biochemistry & Biophysics
Journal title
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
ISSN journal
03011208 → ACNP
Volume
38
Issue
1-2
Year of publication
2001
Pages
120 - 123
Database
ISI
SICI code
0301-1208(200102/04)38:1-2<120:QSAR(S>2.0.ZU;2-0
Abstract
As a part of a composite programme of rational drug design (RDD)(1), Lye ha d synthesized some substituted benzenesulphonyl glutamines and evaluated th eir inhibitory activities against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. Quantitative structure activity relationship (QSAR) studies of these inhibitory activities using Fujita-Ban model as well as Mo dified Hansch-Fujita model gave excellent correlations (correlation coeffic ient r = 0.89 and 0.82 respectively). These results could be useful in desi gning 'lead' compound sith potent inhibitory activity on DNA and RNA synthe sis and tumour development.