OBJECTIVE: To determine whether there is a clinically relevant difference i
n the health state utilities of obese and non-obese individuals as measured
by the Health Utility Index Mark ill.
METHODS: Secondary analysis of the population-based, cross-sectional, inter
viewer-administered National Population Health Survey (NPHS), 1996-1997. A
probability sample of house-dwelling Canadians, excluding populations on Fi
rst Nations Reserves, Canadian Armed Forces Bases, the Yukon and Northwest
Territories, and long-term residents of hospitals or residential care facil
ities. The sub-sample used in this analysis consisted of 38151 respondents(
52.4% male) between the ages of 20 and 64 y, excluding pregnant women. Heal
th Utilities Index-Mark III (HUI3) scores were used to define normal weight
(body mass index (BMI) 19-24.9 kg/m(2)), overweight (BMI 25-29.9 kg/m(2)),
obese (BMI 30-34.9 kg/m(2)), and morbidly obese (BMI greater than or equal
to 35 kg/m(2)) individuals. HUI3 scores were age- and gender-standardized.
RESULTS: The overall prevalence of obesity (BMI greater than or equal to 30
kg/m(2)) in this Canadian population was 13.3%. The average difference in
HUI3 scores between normal weight and morbidly obese respondents was 0.04 (
P < 0.001). Statistically significant (P < 0.05) differences across BMI cat
egories were found in each of the eight component attributes of the HUI3. T
he attributes with the most substantial difference between normal and obese
patients were cognition, mobility and pain. All demonstrated a greater tha
n or equal to 2-fold increase in the proportion of individuals in poorer cl
assifications of health when normal weight respondents were compared with t
he morbidly obese. The magnitude of the decrement in utility ratings associ
ated with obesity was comparable with other chronic non-cardiovascular cond
itions such as migraine or colitis.
CONCLUSION: The results indicate that changes in self-rated health status a
ppear to be due to significant changes across several relevant domain attri
butes. Obesity has a significant impact on both quality of life and health.