Periodontal regeneration with an autogenous bone-Bio-Oss composite graft and a Bio-Gide membrane

This study evaluated the clinical, radiographic, and histologic response to the composite use of Bio-Oss porous bone mineral and autogenous bone in co mbination with a Bio-Gide bilayer collagen membrane to achieve regeneration when treating human periodontal bone defects. Preoperative recordings for four treat ment areas included radiographs, clinical probing depths, and at tachment levels; these recordings were repeated at 9 months. Histologic eva luation revealed new cementum with inserting collagen fibers and new bone f ormation on the surface of both types of graft materials. This grafting com bination not only compared favorably with the previous use of Bio-Oss and B io-Gide, but exceeded that result with almost complete periodontal regenera tion. This human histologic study demonstrates that autogenous bone in comb ination with porous bone mineral matrix, together with the Bio-Gide collage n membrane, has the capacity to stimulate substantial new bone and cementum formation with Sharpey's fiber attachment.