Orbital metastasis in malignant melanoma

We report the case of a 60-year-old man presenting bilateral progressive pr optosis with diplopia, weight loss tachycardia, nervosity, and stomach pain . These signs seemed at first to favor a diagnosis of Graves' ophthalmopath y. Thyroid tests were negative and the initial orbital CT scan was consider ed normal. A new radiological investigation 4 months later in our hospital revealed typical hypertrophy of the extraocular muscles compatible with orb ital metastasis, The systemic investigations demonstrated a pulmonary tumor , multiple hepatic lesions, and several pigmented nodules of gastric mucosa , The pathology of pulmonary and gastric specimens confirmed the diagnosis of malignant melanoma. The primary lesion remains unknown. The authors disc uss the differential diagnoses of orbital metastasis and the radiological c haracteristics of orbital metastasis in malignant melanoma.