A three-drug regimen (gemcitabine, ifosfamide and cisplatin) for advanced non-small-cell lung cancer

Authors
Tognoni, A Pensa, F Vaira, F Vigani, A Bancalari, L Fiasella, L Maggiani, R Canessa, P Pronzato, P
Citation
A. Tognoni et al., A three-drug regimen (gemcitabine, ifosfamide and cisplatin) for advanced non-small-cell lung cancer, J CHEMOTHER, 13(2), 2001, pp. 202-205
Citations number
17
Categorie Soggetti
Pharmacology
Journal title
JOURNAL OF CHEMOTHERAPY
ISSN journal
1120009X → ACNP
Volume
13
Issue
2
Year of publication
2001
Pages
202 - 205
Database
ISI
SICI code
1120-009X(200104)13:2<202:ATR(IA>2.0.ZU;2-N
Abstract
We have carried out a pilot study on 25 non-small cell lung cancer patients , administering the combination of gemcitabine at the dose of 1000 mg/m(2) on days 1 and 8, ifosfamide 1500 mg/m(2) on days 1 and 2 (plus mesna as uro protector) and cisplatin 40 mg/m(2) on days 1 and 2, every 21 days. Granulo cyte Colony Stimulating Factor was employed in all cases from day 10 to day 18 at the dose of 300 mug daily. An objective response was observed in 11 cases (44%), The regimen was active, but toxicity was remarkable with some cases of severe myelosuppression and mucositis.