The predictive power of elevated heart rate for total mortality was evaluat
ed in a Japanese general population. A total of 573 male participants, aged
40 to 64, who underwent a health examination in 1977, were followed until
1994. Heart rate (beats per minute; bpm) was measured using an electrocardi
ogram. During the 18 years, 82 subjects died; 18 from cerebro-cardiovascula
r diseases and 36 from cancer. In a multivariate proportional hazards regre
ssion model, age, elevated systolic and diastolic blood pressures, antihype
rtensive medication, heart rate, uric acid, vital capacity (inversely), and
serum cholesterol (inversely) were significantly associated with all-cause
death. Of these variables, elevated heart rate was the strongest predictor
of all-cause death after adjustment for age. Resting heart rate levels wer
e classified into five groups: <60 (G1), 60-69 (G2), 70-79 (G3), 80-89 (G4)
, and <greater than or equal to>90 (G5) bpm. Heart rates of 60-69 (G2) bpm
showed the lowest death rate (14.3%) and heart rate greater than or equal t
o 90 (G5) bpm showed the highest death rate (38.2%) after adjustments for a
ge and other confounding factors. The relative risk of G2 versus G5 was 2.6
8. An increased mortality risk was shown in men whose heart rate was greate
r than or equal to 90 bpm. Moreover, a continuous model suggested a graded
increase in risk, so that risk is likely elevated even for heart rates less
than 90 bpm, and lowest risk may be around 60 bpm. (C) 2001 Elsevier Scien
ce Inc. All rights reserved.