Breast cancer cellular proliferation indexes and 99mTc-sesta MIBI capture:What correlation?

Aim of this study was to verify existing correlations between bl east cance r 99mTc-sestaMIBI cells uptake and their cytological characteristics. Forty -five patients with clinically and/or mammographically suspect breast cance r were enrolled. In all patients 99mTc-sestaMIBI scintimammography was perf ormed and malignant lesions were detected in 44 cases and benign in one cas e. In positive uptake(PU) lesions with diameter <1.5cm, 85.7% showed a high tumor grade (II-III<degrees>) while in negative uptake (NU) lesions with d iameter <1.5cm, 100% showed a low tumor grade (I<degrees>). In PU lesions, 70% had expressed a high value of Ki 67, while 100% of the NU lesions showe d normal values. In this series, tumor diameter does not play a basic role, while the correlations between uptake and the histological grade (G) and/o r cellular kinetics (Ki67) seem to be more important. Further studies are n eeded to confirm our present results.