A. Sengupta et al., Modulation of DMBA induced genotoxicity in bone marrow by quercetin duringskin carcinogenesis, J EXP CL C, 20(1), 2001, pp. 131-134
Citations number
28
Categorie Soggetti
Oncology
Journal title
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Effect of quercetin was studied on DMBA induced skin carcinogenesis in youn
g adult Swiss albino mice. Quercetin was administered continuously with the
diet (2%) for four weeks and chromosomal aberration, a predictor of future
cancer risk, studied in the bone marrow cells at different time intervals.
Significant reduction of chromosomal aberration was observed in bone marro
w after four weeks (P< 0.02). The reduction was first evident after 96 hrs
though it was not significant at this stage. Significant decrease occurred
from the 21st day onward when quercetin was given in concomitance with 7,12
-dimethylbenz[a] anthracene (DMBA) indicating a definite protective effect
of quercetin on chromosomal aberration.