Hk. Yoon et al., Human papillomavirus 16/18 expression of endocervical glandular lesions: Relationship with p53 and MIB-1 expressions, J KOR MED S, 16(2), 2001, pp. 169-174
The pathogenesis of endocervical glandular lesions are not clearly understo
od. The aims of this study are to evaluate the etiologic role of human papi
llomavirus (HPV) 16/18 and the relationship of HPV 16/18, p53 and MIB-1 exp
ressions in endocervical glandular dysplasia (EGD), adenocarcinoma in situ
(AIS) and adenocarcinoma. The materials included 14 endocervical adenocarci
noma and 5 AIS and 18 high grade EGD and 39 low grade EGD. Immunohistochemi
stry for p53 and MIB-1, and in situ PCR for HPV 16/18 were done. HPV 16/18
positivity was 84.2%, 16.7% and 17.9% in malignant glandular lesion (adenoc
arcinoma and AIS), high grade EGD and low grade EGD, respectively. P53 prot
ein expression rates of malignant glandular lesions, high grade EGD and low
grade EGD were 31.6%, 11.1%, and 0%, respectively. High MIB-1 labelling in
dex was found in 73.7% of malignant glandular lesions, but in only 5.7% and
3.6% of high and low grade EGD, respectively. There were statistically sig
nificant differences in HPV 16/18, p53 and MIB-1 expressions between malign
ant endocervical glandular lesions and EGD, but no significant difference i
n p53 and MIB-1 expressions in relation to HPV 16/18 expression. In maligna
nt endocervical glandular lesions, HPV 16/18 infection may be a major causa
tive factor, but not be related to p53 and MIB-1 expressions.