Human papillomavirus 16/18 expression of endocervical glandular lesions: Relationship with p53 and MIB-1 expressions

Citation
Hk. Yoon et al., Human papillomavirus 16/18 expression of endocervical glandular lesions: Relationship with p53 and MIB-1 expressions, J KOR MED S, 16(2), 2001, pp. 169-174
Citations number
27
Categorie Soggetti
General & Internal Medicine
Journal title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN journal
10118934 → ACNP
Volume
16
Issue
2
Year of publication
2001
Pages
169 - 174
Database
ISI
SICI code
1011-8934(200104)16:2<169:HP1EOE>2.0.ZU;2-G
Abstract
The pathogenesis of endocervical glandular lesions are not clearly understo od. The aims of this study are to evaluate the etiologic role of human papi llomavirus (HPV) 16/18 and the relationship of HPV 16/18, p53 and MIB-1 exp ressions in endocervical glandular dysplasia (EGD), adenocarcinoma in situ (AIS) and adenocarcinoma. The materials included 14 endocervical adenocarci noma and 5 AIS and 18 high grade EGD and 39 low grade EGD. Immunohistochemi stry for p53 and MIB-1, and in situ PCR for HPV 16/18 were done. HPV 16/18 positivity was 84.2%, 16.7% and 17.9% in malignant glandular lesion (adenoc arcinoma and AIS), high grade EGD and low grade EGD, respectively. P53 prot ein expression rates of malignant glandular lesions, high grade EGD and low grade EGD were 31.6%, 11.1%, and 0%, respectively. High MIB-1 labelling in dex was found in 73.7% of malignant glandular lesions, but in only 5.7% and 3.6% of high and low grade EGD, respectively. There were statistically sig nificant differences in HPV 16/18, p53 and MIB-1 expressions between malign ant endocervical glandular lesions and EGD, but no significant difference i n p53 and MIB-1 expressions in relation to HPV 16/18 expression. In maligna nt endocervical glandular lesions, HPV 16/18 infection may be a major causa tive factor, but not be related to p53 and MIB-1 expressions.