Chiral platinum and palladium complexes containing functionalized C-2-symmetric bisaminoaryl 'Pincer' ligands

The synthesis of enantiopure (oxo-functionalized) C-2-symmetric NCN pincer ligands is described. A key step is the symmetric functionalization of the benzylic positions, which was achieved by enantioselective ketone reduction and subsequent stereoselective substitution protocols. The introduction of alpha -alkyl substituents has a pronounced effect on the cavity for metal binding. For example, lithiation of the alpha -ethyl-functionalized pincer ligand afforded mixed (alkyl)(aryl)lithium aggregates rather than dinuclear bis(aryl) lithium [Li(NCN)](2) species as usually observed for NCN-lithium complexes. Similar effects were established or the (trans)-metalation reac tion, which proceeded significantly slower when the steric demand of the al pha -substituent is increased. The potential of the corresponding enantiopu re palladium and ruthenium complexes as enantioselective catalyst has been probed in the asymmetric aldol condensation and hydrogen transfer reactions . The low enantiomeric excess of the products of both reactions indicated t hat face-discrimination of substrates is not induced by these catalysts and that the chiral information must be located in closer proximity to the met al center. (C) 2001 Elsevier Science B.V. All rights reserved.