Electrochemical reduction and cathodic stripping voltammetric determination of clotrimazole

The reduction of clotrimazole at a mercury electrode, in phosphate buffer, pH>6, involves a reversible one-electron process. The electrochemical proce ss presents a large contribution from adsorption effects. For the different ial pulse polarographic determination the addition of Triton X-100 is recom mended. Clotrimazole can be determined by cathodic stripping voltammetry at 50 ng mL(-1) level when pre-accumulated for 3 min at an accumulation poten tial of -0.20 V. The proposed method is applied successfully for the determ ination of clotrimazole in a commercial formulation.