Impact of nosocomial infections in trauma: Does age make a difference?

Background: The effect of age and infection on outcome after trauma is unkn own. We evaluated the incidence and impact that nosocomial infection (NI) a nd age have on morbidity and mortality, Several risk factors were identifie d and analyzed for correlation dth infection. Methods: Prospective data were collected an patients admitted for greater t han or equal to 3 days over a 2-year period. Each patient was followed by a n infectious disease specialist throughout their hospitalization. Centers f or Disease Control and Prevention guidelines were used to diagnose infectio n. Results:Of the 3,254 patients admitted, 88% were < 65 and 12% were <greater than or equal to> 65 years of age. Injury Severity Store was not significa ntly different (alder vs. younger), Five hundred one (17.4%) of the younger patients del eloped an NI with a significantly higher hospital length of s tay (LOS), intensive care unit (ICU) LOS, and mortality compared with the n oninfected group. One hundred forty-seven (39%) of the older group develope d an NI and also had significant increases in hospital LOS, ICU LOS, and mo rtality: Older infected patients had the highest hospital LOS, ICU LOS, and mortality, The greatest relative risk of mortality was demonstrated with t he combination of increased age and NI. Once infected, however, younger pat ients with penetrating trauma had a greater relative risk of mortality in t he group-specific comparison. Many risk factors were associated with infect ion, Only chronic obstructive pulmonary disease in elderly trauma patients was a significant independent risk factor for infection. Conclusion: NI significantly increases hospital LOS, ICU LOS, and mortality after injury, Age increases risk of infection matched for injury severity, with a significantly higher hospital LOS, ICU LOS, and mortality. Once inf ected, however, younger patients with penetrating trauma have the greatest risk of mortality, Chronic obstructive pulmonary disease in elderly trauma patients was found to he an independent predictor of infection.