Oxidative stress is reduced by the long-term use of vitamin E-coated dialysis filters

Background. Oxidative stress during hemodialysis is thought to promote the progression of vascular complications in hemodialysis patients. The protect ive role of vitamin E as a lipophilic antioxidant against oxidative stress has been widely investigated. Here we investigated the effects of a vitamin E-coated regenerated cellulose hollow fiber dialyzer (CL-EE) on oxidative stress compared with a polysulfone hollow fiber (CL-PS). Methods. Far at least three months before beginning the protocol, 10 nondia betic (NDM) patients (70.0 +/- 7.5 years; 6 males and 4 females) and S diab etic (DM) patients (65.0 +/- 7.4 years; 4 males, 4 females) were dialyzed w ith CL-PS. After that, we treated all of the patients with CL-EE for six mo nths. Malondialdehyde (MDA) advanced glycation end products (AGEs), and 8-h ydroxydeoxyguanosine (8-OHdG) were monitored as biomarkers for oxidative st ress at the start and then at one, three, and six months into treatment wit h CL-EE. Results. Serum MDA, AGE, and 8-OHdG levels increased after the hemodialysis with CL-PS. The increase of the biomarkers was completely prevented by a s ingle use of CL-EE. Long-term hemodialysis with CL-EE for sir; months signi ficantly reduced the basal levels of the oxidant markers at one month for A GE and at six months for 8-OHdG in both DM and NDM patients, Serum MDA was reduced in only DM patients at three months. The improvement of the oxidati ve stress with CL-EE was more prominent in the DM patients. Conclusions. Long-term treatment with CL-EE efficiently improves the oxidat ive stress associated with hemodialysis and potentially reduces dialysis co mplications due to oxidative stress.