Subcutaneous extramedullary hematopoiesis in a patient with secondary myelofibrosis following polycythemia vera

We describe the case of a 73-year-old woman with secondary myelofibrosis wh o developed subcutaneous extramedullary hematopoiesis. Although extramedull ary hematopoiesis has been generally observed in primary myelofibrosis. in this case it was seen in myelofibrosis secondary to polycythemia vera. Hist ological examination of the subcutaneous nodule revealed that the lesion in cluded cells from the myeloid and megakaryocytic series. The skin lesion al most disappeared after treatment with hydroxyurea. U e report here this rar e manifestation in secondary myelofibrosis including a review of literature .