Diet and lupus

The effect of dietary modifications has been extensively studied in lupus a nimal models. Calorie, protein, and especially fat restriction, caused a si gnificant reduction in immune-complex deposition in the kidney, reduced pro teinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or li nseed oil, was also related to decreased mice morbidity and mortality in an imal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosa petaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit a rachidonic acid with a resultant decrease in inflammmatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrological ly and clinically. Large scale clinical studies are needed to confirm the p rimary results.