A case of systemic lupus erythematosus complicated with multicentric reticulohistiocytosis (MRH): successful treatment of MRH and lupus nephritis with cyclosporin A

We document the first case of a patient who manifested systemic lupus eryth ematosus (SLE) complicated with multicentric reticulohistiocytosis (MRH). N either intravenous steroid nor cyclophosphamide (CY) pulse therapies were f ully effective against multiple MRH-related tumors that appeared on the lef t ankle joint and interphalangeal joints of both hands. In contrast, treatm ent with cyclosporin A (CyA) resulted in a marked regression of these nodul es within one month, together with a complete remission of both MRH and lup us nephritis. We propose CyA as an alternative choice for the treatment of MRH.