BEHAVIORS AND NEURODEGENERATION INDUCED BY 2 BLOCKERS OF K-CELL DEGRANULATING PEPTIDE AND DENDROTOXIN-I( CHANNELS, THE MAST)

Authors
MOURRE C LAZDUNSKI M JARRARD LE
Citation
C. Mourre et al., BEHAVIORS AND NEURODEGENERATION INDUCED BY 2 BLOCKERS OF K-CELL DEGRANULATING PEPTIDE AND DENDROTOXIN-I( CHANNELS, THE MAST), Brain research, 762(1-2), 1997, pp. 223-227
Citations number
15
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
762
Issue
1-2
Year of publication
1997
Pages
223 - 227
Database
ISI
SICI code
0006-8993(1997)762:1-2<223:BANIB2>2.0.ZU;2-B
Abstract
Both the Mast Cell Degranulating (MCD) peptide and Dendrotoxin I (DTXI ), two blockers of fast activation and slowly inactivating K+ channels , induced epileptiform seizures and brain damage after intracerebroven tricular injection (200 pmol) in Sprague-Dawley rats. A considerable v ariation in the response of the rats was observed for each toxin. The neurodegeneration included the hippocampal formation, subiculum, septu m, amygdala, and the cerebellum for both toxins, and the neocortex and anterior thalamic nuclei exclusively for DTXI treatment. (C) 1997 Els evier Science B.V.