DELAYED NEURONAL DEATH PREVENTED BY INHIBITION OF INCREASED HYDROXYL RADICAL FORMATION IN A TRANSIENT CEREBRAL-ISCHEMIA

Authors
YAMAMOTO T YUKI S WATANABE T MITSUKA M SAITO K KOGURE K
Citation
T. Yamamoto et al., DELAYED NEURONAL DEATH PREVENTED BY INHIBITION OF INCREASED HYDROXYL RADICAL FORMATION IN A TRANSIENT CEREBRAL-ISCHEMIA, Brain research, 762(1-2), 1997, pp. 240-242
Citations number
16
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
762
Issue
1-2
Year of publication
1997
Pages
240 - 242
Database
ISI
SICI code
0006-8993(1997)762:1-2<240:DNDPBI>2.0.ZU;2-J
Abstract
The salicylate-trapping method was used to detect hydroxyl radicals by measurement of stable adduct dihydroxybenzoic acid (DHBA). Ten minute s of forebrain ischemia followed by reperfusion induced the increase i n DHBA in rat hippocampal perfusates. Postischemic treatment with a fr ee radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), s ignificantly reduced the increase in DHBA and suppressed delayed neuro nal death in the hippocampal CA1 region. (C) 1997 Elsevier Science B.V .