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The salicylate-trapping method was used to detect hydroxyl radicals by
measurement of stable adduct dihydroxybenzoic acid (DHBA). Ten minute
s of forebrain ischemia followed by reperfusion induced the increase i
n DHBA in rat hippocampal perfusates. Postischemic treatment with a fr
ee radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), s
ignificantly reduced the increase in DHBA and suppressed delayed neuro
nal death in the hippocampal CA1 region. (C) 1997 Elsevier Science B.V
.