DNA-binding by Ig-fold proteins

Authors
Rudolph, MJ Gergen, JP
Citation
Mj. Rudolph et Jp. Gergen, DNA-binding by Ig-fold proteins, NAT ST BIOL, 8(5), 2001, pp. 384-386
Citations number
30
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
8
Issue
5
Year of publication
2001
Pages
384 - 386
Database
ISI
SICI code
1072-8368(200105)8:5<384:DBIP>2.0.ZU;2-L
Abstract
Recent structures of the Runx1-CBF beta heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families th at use an immunoglobulin (Ig) fold to bind to DNA. Variation in the loop re gions accounts for the diversity of DNA sequences recognized by Ig-fold pro teins, but there are recurring themes in the interactions made by specific loop regions and how these interactions are regulated.