Cerebral involvement in graft-versus-host disease after murine bone marrowtransplantation

Neurologic manifestation of graft-versus-host, disease (GvHD) after allogen eic bone marrow transplantation (BMT) has until now been limited to rare ne uromuscular syndromes. Investigating cerebral findings using a murine BMT m odel, the authors found parenchymal lymphocytic inflammation, microglia act ivation, and mild cerebral angiitis-like changes in allogeneic transplanted animals but not in syngeneic controls. These findings suggest that cerebra l involvement during GvHD may be a new neurologic complication after BMT.