The authors evaluated education attainment and neuro-psychological deficits
in children with sickle cell disease (SCD) and silent cerebral infarcts. C
hildren with silent infarcts had twice the rate of school difficulties as c
hildren without infarcts. Eighty percent of silent infarct cases had clinic
ally significant cognitive deficits, whereas 35% had deficits in academic s
kills. Children with silent cerebral infarcts show high rates of poor educa
tional attainment, cognitive deficits, and frontal lobe injury. Poor school
performance in SCD is one indicator of silent infarcts.