Celiac vagotomy reduces suppression of feeding by jejunal fatty acid infusions

We investigated the role of the celiac branch of the vagus nerve in suppres sion of food intake produced by jejunal fatty acids infusions. Following se lective celiac vagotomy or sham surgery, adult, male Sprague-Dawley rats re ceived 7 h infusions of linoleic acid or saline through indwelling jejunal catheters on four consecutive days. Although linoleic acid still produced s ignificant suppression of intake in rats with celiac vagotomy, it was less effective in these animals than in controls. The temporal pattern of result s suggested that celiac afferent fibers are involved in mediating both pre- and postabsorptive effects of infused fatty acids. NeuroReport 12:1093-109 6 (C) 2001 Lippincott Williams & Wilkins.