Uptake of Re-188-beta-naphthyl-peptide in cervical carcinoma tumours in athymic mice

Radiolabelled somatostatin analogues have been used in diagnostic and thera peutic nuclear medicine to treat cancerous tumours. Lanreotide, a cyclic oc tapeptide, beta -naphthyl-peptide, with antiproliferative action on human s mall cell lung carcinoma was Re-188 labelled and characterised, and its bio distribution was studied in mice. Molecular modelling indicates that the li pophilic radiopharmaceutical might be an oxo-rhenium (V) penta-coordinated complex. The implanted human cervical tumour of epidermoid origin was posit ive for cytokeratins and Vimentin. Uptake of Re-188-labelled peptide in the implanted tumour in athymic mice was 6.2+/-2.9% and was rapidly cleared vi a the hepatobiliary system. Re-188-beta -naphthyl-peptide might be a potent ial therapeutic agent. (C) 2001 Elsevier Science Inc. All rights reserved.