M. Wallock et al., Evaluation of a new point of care heparin test for cardiopulmonary bypass:the TAS heparin management test, PERFUSION-U, 16(2), 2001, pp. 147-153
Patients undergoing cardiopulmonary bypass (CPB) require anticoagulation wi
th heparin to avoid thrombosis within the bypass circuit. The common method
used to monitor the degree of anticoagulation is the activated clotting ti
me (ACT). We evaluated a novel point of care device, the TAS (Pharmanetics,
Raleigh, NC, USA) heparin management test (HMT), for its suitability in mo
nitoring anticoagulation during CPB. In vitro analysis showed a dose-respon
se (r(2)=0.988) of the HMT from 0.078-10.0 U/ml heparin, covering the range
of heparin used during cardiac surgery (2-5 U/ml). Fifty randomly selected
patients undergoing CPB were studied. Preheparin clotting times for these
patients were 143+/-32 s for the HMT and 146+/-18 s for the ACT; 435+/-60 s
HMT and 438+/-39 a ACT during CPB, 145+/-50 a HMT and 128+/-14 s ACT post-
protamine (r(2)=0.797). epsilon -Aminocaproic acid treatment for inhibition
of fibrinolysis did not affect the HMT. We conclude that the HMT correlate
s well with the ACT and may be useful for monitoring heparin during CPB. Ad
vantages of the HMT are small sample volume and good sensitivity to heparin
.