A sesquiterpene drimane with antinociceptive activity from Drimys winteri bark

Authors
Malheiros, A Cechinel, V Schmitt, CB Santos, ARS Scheidt, C Calixto, JB Delle Monache, F Yunes, RA
Citation
A. Malheiros et al., A sesquiterpene drimane with antinociceptive activity from Drimys winteri bark, PHYTOCHEM, 57(1), 2001, pp. 103-107
Citations number
20
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
57
Issue
1
Year of publication
2001
Pages
103 - 107
Database
ISI
SICI code
0031-9422(200105)57:1<103:ASDWAA>2.0.ZU;2-Q
Abstract
Along with three known drimanes, polygodial, 1-beta-(p-methoxycinnamoyl) po lygodial and mukaadial, the sesquiterpene drimane named drimanial was isola ted from the bark of Drimys winteri (Winteraceae). Its structure was elucid ated based on spectroscopic evidence. Drimanial exhibited antinociceptive a ction against acetic acid induced pain, being about 3-fold less active than polygodial. (C) 2001 Elsevier Science Ltd. All rights reserved.