A new antimycobacterial, 3 beta-acetoxy-15 alpha,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata

Authors
Boonphong, S Kittakoop, P Isaka, M Palittapongarnpim, P Jaturapat, A Danwisetkanjana, K Tanticharoen, M Thebtaranonth, Y
Citation
S. Boonphong et al., A new antimycobacterial, 3 beta-acetoxy-15 alpha,22-dihydroxyhopane, from the insect pathogenic fungus Aschersonia tubulata, PLANTA MED, 67(3), 2001, pp. 279-281
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
3
Year of publication
2001
Pages
279 - 281
Database
ISI
SICI code
0032-0943(200104)67:3<279:ANA3BA>2.0.ZU;2-1
Abstract
Bioassay-guided fractionation of the cell extract of the insect pathogenic fungus Aschersonia tubulata BCC 1785 led to the isolation of dustanin (1), 3 beta ,15 alpha ,22-trihydroxyhopane (3), 5 alpha ,8 alpha -epidioxy-24(R) -methylcholesta-6,22-diene-3 beta -ol (6), together with the new 3 beta -ac etoxy-15 alpha ,22-dihydroxyhopane (4). Chemical structures of these compou nds were elucidated by spectral analyses as well as chemical transformation . Compounds 1 and 4 exhibited antimycobacterial activity with the minimum i nhibitory concentration (MIC) of 12.5 mug/ml.