Radiation-induced granulocyte transmigration predicts development of delayed structural changes in rat intestine

Authors
Richter, KK Wang, JR Fagerhol, MK Hauer-Jensen, M
Citation
Kk. Richter et al., Radiation-induced granulocyte transmigration predicts development of delayed structural changes in rat intestine, RADIOTH ONC, 59(1), 2001, pp. 81-85
Citations number
30
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
RADIOTHERAPY AND ONCOLOGY
ISSN journal
01678140 → ACNP
Volume
59
Issue
1
Year of publication
2001
Pages
81 - 85
Database
ISI
SICI code
0167-8140(200104)59:1<81:RGTPDO>2.0.ZU;2-K
Abstract
We examined whether early radiation-induced granulocyte transmigration (ass essed by the fecal transferrin excretion ELISA assay) predicts subsequent d evelopment of (consequential) chronic radiation enteropathy. After accounti ng for the effect of radiation dose, transferrin excretion remained an inde pendent predictor of overall tissue injury, intestinal fibrosis, and mucosa l ulcers, but not TGF-beta immunoreactivity. (C) 2001 Elsevier Science Irel and Ltd. All rights reserved.