2,6-diamino-3,5-diaryl-1,4-pyrazine derivatives as novel antioxidants

Authors
Cavalier, JF Burton, M De Tollenaere, C Dussart, F Marchand, C Rees, JF Marchand-Brynaert, J
Citation
Jf. Cavalier et al., 2,6-diamino-3,5-diaryl-1,4-pyrazine derivatives as novel antioxidants, SYNTHESIS-S, (5), 2001, pp. 768-772
Citations number
28
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
5
Year of publication
2001
Pages
768 - 772
Database
ISI
SICI code
0039-7881(200104):5<768:2DANA>2.0.ZU;2-7
Abstract
The coupling of arylboronic acids with 2,6-diamino-3,5-dibromo-1,4-pyrazine (6) gave 2,6-diamino-3,5-diaryl-1,4-pyrazines (7). The reaction of 7 with methyl glyoxal in aqueous EtOH-HCl led to the N,N'-disubstituted products 8 , instead of the expected bicyclic imidazolopyrazinones 1. The 2,6-bis[1-(e thoxycarbonyl)ethylamino]-3,5-diaryl-1,4-pyrazines 8 are powerful inhibitor s of the AAPH-induced linoleate peroxidation.