Heterolignanolides, Furo- and thieno-analogues of podophyllotoxin and thuriferic acid

Authors
Ramos, AC Pelaez, R Lopez, JL Caballero, E Medarde, M Feliciano, AS
Citation
Ac. Ramos et al., Heterolignanolides, Furo- and thieno-analogues of podophyllotoxin and thuriferic acid, TETRAHEDRON, 57(18), 2001, pp. 3963-3977
Citations number
41
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
18
Year of publication
2001
Pages
3963 - 3977
Database
ISI
SICI code
0040-4020(20010430)57:18<3963:HFATOP>2.0.ZU;2-A
Abstract
The conjugate addition-alkylation to 5H-furan-2-one followed by cyclization and controlled epimerizations have been applied to the synthesis of new fu ro- and thieno-lignan analogues. Podophyllotoxin and thuriferic acid hetero analogues have been obtained by this methodology, as representative members of these families. (C) 2001 Elsevier Science Ltd. All rights reserved.