Isoimmune neonatal neutropenia due to anti-Fc(gamma) RIIIb antibody in a mother with an Fc(gamma) RIIIb deficiency

Citation
K. Maslanka et al., Isoimmune neonatal neutropenia due to anti-Fc(gamma) RIIIb antibody in a mother with an Fc(gamma) RIIIb deficiency, TRANSFUS M, 11(2), 2001, pp. 111-113
Citations number
14
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
TRANSFUSION MEDICINE
ISSN journal
09587578 → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
111 - 113
Database
ISI
SICI code
0958-7578(200104)11:2<111:INNDTA>2.0.ZU;2-E
Abstract
A rare case of neutropenia in a newborn due to anti-Fc(gamma) RIIIb antibod y is described. The newborn, born from the 5th pregnancy, had severe infect ion and no neutrophils. Full clinical and neutrophil count recovery was obs erved when the child was 5 weeks old. In maternal serum, panreactive granul ocyte alloantibodies were detected. The mother's and her two sisters' granu locytes appeared to be F-gamma RIIIb deficient as found using pheno- and ge notyping methods. All of them were healthy. The anti-Fc(gamma) RIIIb specif icity of antibodies was identified by the monoclonal antibody immunobilizat ion of neutrophil antigen assay. Such antibodies were not found in both sis ters with the Fc(gamma) RIIIb deficiency, although they were pregnant, one of them on the seventh occasion.