Surface expression of Kv1 voltage-gated K+ channels is governed by a C-terminal motif

The normal rhythmic beating of the heart relies on tight control of express ion of voltage-gated ion channels in the plasma membrane of cardiac myocyte s. Recently, a conserved motif was identified near the C-terminus of Kv1 vo ltage-gated K+ channels that is required for efficient processing and surfa ce expression. Furthermore, variations in the motif account for differences among normal channels in localization and the requirement for auxiliary su bunits for robust expression. Thus, this motif is a key regulator of cell s urface expression of Kv1 family K+ channels. (Trends Cardiovasc Med 2000;10 :317-320). (C) 2001, Elsevier Science Inc.