Update on the role of leukotrienes in the pathogenesis of atopy: a comparative review

The pathogenesis of atopic disease (AD) is controversial in humans and dogs . In humans, leukotrienes (LT) are thought to play an important role in thi s disease and LT inhibitors are commonly used as treatment for AD. Leukotri enes are a heterogenous group of biologically active compounds that mediate many aspects of inflammatory and allergic reactions. This paper will revie w the role of LT in atopic disease in a comparative manner. Leukotriene inh ibitors and their therapeutic use in the management of atopic disease in hu mans and dogs are discussed.