CHEMOENZYMATIC PREPARATION OF ENANTIOPURE PARTIAL ESTERS OF CONDURITOL-E

Authors
SANFILIPPO C PATTI A PIATTELLI M NICOLOSI G
Citation
C. Sanfilippo et al., CHEMOENZYMATIC PREPARATION OF ENANTIOPURE PARTIAL ESTERS OF CONDURITOL-E, Tetrahedron : asymmetry, 8(13), 1997, pp. 2083-2084
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
13
Year of publication
1997
Pages
2083 - 2084
Database
ISI
SICI code
0957-4166(1997)8:13<2083:CPOEPE>2.0.ZU;2-J
Abstract
Two partial esters of conduritol E, namely (2R)-hydroxy-(1R,3R,4R)-tri acetoxycyclohex-5-ene and (1S,2S)-dihydroxy-(3S,4S)-diacetoxycyclohex- 5-ene, have been prepared in high chemical and optical yields from 'be nzene cis-glycol' diacetate via OsO4 catalysed dihydroxylation followe d by enantioselective esterification of the resulting conduritol E dia cetate in the presence of Mucor miehei lipase. (C) 1997 Elsevier Scien ce Ltd.