D. Braghiroli et al., ASYMMETRIC-SYNTHESIS OF (R)-2-PYRROLIDINEMETHANESULFONIC AND (S)-2-PYRROLIDINEMETHANESULFONIC ACID, Tetrahedron : asymmetry, 8(13), 1997, pp. 2209-2213
(R)- and (S)-2-Pyrrolidinemethanesulfonic acid, 3a and 3b, were synthe
sized from the corresponding N-Boc-2-(hydroxymethyl)-1-pyrrolidine, 6a
and 6b. This asymmetric synthesis proceeds in mild conditions, with g
ood overall yields and high enantiomeric purities (>99% ee). (C) 1997
Elsevier Science Ltd.