ASYMMETRIC-SYNTHESIS OF (R)-2-PYRROLIDINEMETHANESULFONIC AND (S)-2-PYRROLIDINEMETHANESULFONIC ACID

Authors
BRAGHIROLI D AVALLONE R DIBELLA M
Citation
D. Braghiroli et al., ASYMMETRIC-SYNTHESIS OF (R)-2-PYRROLIDINEMETHANESULFONIC AND (S)-2-PYRROLIDINEMETHANESULFONIC ACID, Tetrahedron : asymmetry, 8(13), 1997, pp. 2209-2213
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
13
Year of publication
1997
Pages
2209 - 2213
Database
ISI
SICI code
0957-4166(1997)8:13<2209:AO(A(>2.0.ZU;2-C
Abstract
(R)- and (S)-2-Pyrrolidinemethanesulfonic acid, 3a and 3b, were synthe sized from the corresponding N-Boc-2-(hydroxymethyl)-1-pyrrolidine, 6a and 6b. This asymmetric synthesis proceeds in mild conditions, with g ood overall yields and high enantiomeric purities (>99% ee). (C) 1997 Elsevier Science Ltd.