Community-based controlled trial of dietary management of children with persistent diarrhea: sustained beneficial effect on ponderal and linear growth

Background: Uncontrolled hospital-based studies in developing countries hav e reported promising results of dietary rehabilitation of children with per sistent diarrhea. Objective: The objective was to determine the immediate and long-term effec ts of a dietary supplement and micronutrients given to children with persis tent diarrhea during the episode and for 1 wk during convalescence. Design: The study was open, controlled, and community-based and was conduct ed in a periurban area in Guinea-Bissau. Children <3 y of age with persiste nt diarrhea were identified during weekly household visits. The children ra ndomly assigned to the treatment and control groups were examined by a phys ician and all medical conditions were treated. The children in the treatmen t group were offered home-based dietary treatment consisting of locally ava ilable foods and micronutrient supplements. Results: There were 141 episodes of persistent diarrhea during the study: 7 0 in the treatment group (in 58 children) and 71 in the control group (in 6 2 children). During the intervention period (median: 17 d), weight gain in the treatment group exceeded that of the control group by 61.5 g/wk (95% CI : 49.2, 73.8), whereas there was no significant difference in linear growth on the basis of knee-heel length. At a median follow-up period of 6.6 mo a fter the intervention was stopped, weight gain in the treatment group excee ded that of the control group by 12.5 g/wk (95% CI: 7.7, 17.3); knee-heel l ength was 7.5 mm/y (4.8, 10.2) greater and total length was 0.65 cm/y (0.11 , 1.19) greater in the treatment group. Conclusion: Therapeutic feeding and micronutrient supplementation had an im mediate and sustained beneficial effect on growth in children with persiste nt diarrhea.