Allogeneic transplantation of blood stem cells: Coming of age?

Mobilized peripheral blood progenitor cells (PBSC) are increasingly being u sed instead of bone marrow for allogeneic transplantation. The purpose of t he present article is to give a concise and clinically oriented overview on current results and perspectives of allogeneic peripheral blood stem cell transplantation, with particular focus on reconstitution of hematopoiesis a nd the immune system, graft-versus-host disease, graft-versus-leukemia effe cts, intensity-reduced conditioning, and graft engineering.