Interactions between monoamines, glutamate, and GABA in schizophrenia: Newevidence

In spite of its proven heuristic value, the dopamine hypothesis of schizoph renia is now yielding to a multifactorial view, in which the other monoamin es as well as glutamate and GABA are included, with a focus on neurotransmi tter interactions in complex neurocircuits. The primary lesion(s) in schizo phrenia does not necessarily involve any of these neurotransmitters directl y but could deal with a more general defect, such as a faulty connectivity of developmental origin. Nevertheless, a precise identification of neurotra nsmitter aberrations in schizophrenia will probably provide clues for a bet ter understanding of the disease and for the development of new treatment a nd prevention strategies.