Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population

Associations between genetic polymorphisms of CYP1A1, CYP1A2, CYP2E1, GSTM1 and GSTT1 and prostate cancer (PCa) were analyzed in a case-control study of 315 individuals. The frequency of valine (Val)/valine (Val) genotypes fo r CYP1A1 was 11.3% in cases compared with 5.5% in controls, this polymorphi sm thus being associated with a significantly increased risk of PCa (odds r atio = 2.4, 95% confidence interval (CI) = 1.01-5.57). No links were detect ed between PCa and polymorphisms in other enzymes. However, the combination of CYP1A1 (Ile/Val and/or Val/Val) polymorphisms with the GSTM1 null type resulted in an OR of 2.2 (CI = 1.10-4.57, 1.12-4.20, respectively). This st udy suggests that the CYP1A1 polymorphism and its combination with GSTM1 ma y be associated with PCa susceptibility in the Japanese population. (C) 200 1 Elsevier Science Ireland Ltd. All rights reserved.