In vivo activity of CHS 828 on hollow-fibre cultures of primary human tumour cells from patients

Authors
Jonsson, E Friberg, LE Karlsson, MO Hassan, SB Nygren, P Kristensen, J Tholander, B Binderup, L Larsson, R
Citation
E. Jonsson et al., In vivo activity of CHS 828 on hollow-fibre cultures of primary human tumour cells from patients, CANCER LETT, 162(2), 2001, pp. 193-200
Citations number
14
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
03043835 → ACNP
Volume
162
Issue
2
Year of publication
2001
Pages
193 - 200
Database
ISI
SICI code
0304-3835(20010126)162:2<193:IVAOC8>2.0.ZU;2-8
Abstract
Fresh human tumour cells from patients with ovarian cancer and chronic lymp hocytic leukaemia were cultured in semipermeable hollow fibres. The fibres were implanted on immunocompetent rats, which were treated with the cyanogu anidine N-(4-chlorophenoxyhexyI)-N'-cyano-N"-4-pyridylguanidine(CHS 828). C HS 828 showed high antitumour activity against all eight tumour samples; th e fibres from control animals had a mean net growth of 73% while CHS 828 tr eatment induced a 37% mean reduction of cell density, without observable ha ematological toxicity. The results show a feasibility of using tumour cells directly from patients in the hollow-fibre rat model. (C) 2001 Elsevier Sc ience Ireland I,td. All rights reserved.