Glycosylation of 2-thiohydantoin derivatives. Synthesis of some novel S-alkylated and S-glucosylated hydantoins

Authors
Khodair, AI
Citation
Ai. Khodair, Glycosylation of 2-thiohydantoin derivatives. Synthesis of some novel S-alkylated and S-glucosylated hydantoins, CARBOHY RES, 331(4), 2001, pp. 445-453
Citations number
25
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE RESEARCH
ISSN journal
00086215 → ACNP
Volume
331
Issue
4
Year of publication
2001
Pages
445 - 453
Database
ISI
SICI code
0008-6215(20010423)331:4<445:GO2DSO>2.0.ZU;2-3
Abstract
3-Aryl-5-((Z)-arylidene)-3-aryl-2-(2-methylthioethyl)-2-thiohydantoins 3a-f and 3-aryl-5-((Z)-arylidene)-2- (2',3',4',6'-tetra-O-acetyl-beta -D-glucop yranosyl)-2-thiohydantoins 7a-n were prepared from the reaction of 3-aryl-5 -((Z)-arylidene)-2-thiohydantoins 2a-n with methylthioethyl chloride or 2', 3',4',6'-tetra-O-acetyl-alpha -D-glucopyranosyl bromide via three different routes. The compounds did not display any antiviral and antitumoral activi ty. (C) 2001 Elsevier Science Ltd. All rights reserved.