Sumatriptan: economic evidence for its use in the treatment of migraine, the Canadian comparative economic analysis

The objective of this study was to evaluate economic and health effects of sumatriptan relative to customary therapy in Canada. The relationship betwe en treatment and functionality was established based on analysis of existin g data from a multinational study. A Monte Carlo model was developed to sim ulate 1 year for each of customary therapy and six sumatriptan formulations . Costs are expressed in 1998 Canadian dollars. Sumatriptan is expected to reduce the time spent with migraine symptoms and resulting time lost. Under customary therapy, the annual cost of lost time is estimated at pound 908 ($1973). With sumatriptan, these costs ranged from pound 406 ($882) with su bcutaneous sumatriptan to pound 577 ($1254) with nasal sumatriptan 10 mg, s aving pound 3331-502 ($719-1091) in the annual cost of time lost. All these benefits are expected to be obtained at an additional drug cost ranging fr om pound 869 ($1889) for subcutaneous sumatriptan to pound 278 ($605) for s umatriptan suppository The cost of sumatriptan treatment is significantly o ffset by a substantial reduction of costs associated with time lost due to migraine symptoms.