Citation
R. Wan et al., Studies on DNA cleaved by seryl-histidine dipeptide, CHEM J CH U, 22(4), 2001, pp. 598-600
Citations number
8
Categorie Soggetti
Chemistry
Journal title
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN journal
02510790
→ ACNP
Volume
22
Issue
4
Year of publication
2001
Pages
598 - 600
Database
ISI
SICI code
0251-0790(200104)22:4<598:SODCBS>2.0.ZU;2-0
Abstract
Linear and supercoiled DNA were cleaved by HPLC purified seryl-histidine di
peptide(SH). It was found that the DNA fragments produced by the reaction o
f SH and DNA could be ligated together by T-4 DNA ligase. This result impli
ed that the SH was the first example of the ion-free artificial DNA cleavag
e agent that could split DNA by hydrolysis mechanism.