The synthesis of optically pure enantiomers of N-acyl-homoserine lactone autoinducers and their analogues

Authors
Ikeda, T Kajiyama, K Kita, T Takiguchi, N Kuroda, A Kato, J Ohtake, H
Citation
T. Ikeda et al., The synthesis of optically pure enantiomers of N-acyl-homoserine lactone autoinducers and their analogues, CHEM LETT, (4), 2001, pp. 314-315
Citations number
10
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
4
Year of publication
2001
Pages
314 - 315
Database
ISI
SICI code
0366-7022(20010405):4<314:TSOOPE>2.0.ZU;2-E
Abstract
Optically pure enantiomers of N-acyl-homoserine lactones and thiolactones, whose optical purities were unambiguously determined by chiral stationary p hase HPLC analyses, were firstly synthesized. Bioassays revealed that L-iso mers were essential as the autoinducers in quorum sensing, while no effect was observed with D-isomers.