A cyclic sugar unit interacts more strongly with DNA than do open-chain polyol counterparts in sugar-linked synthetic DNA intercalators

Authors
Kumasaki, A Goto, T Nakamura, S Ihara, T Takagi, M
Citation
A. Kumasaki et al., A cyclic sugar unit interacts more strongly with DNA than do open-chain polyol counterparts in sugar-linked synthetic DNA intercalators, CHEM LETT, (4), 2001, pp. 370-371
Citations number
19
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
4
Year of publication
2001
Pages
370 - 371
Database
ISI
SICI code
0366-7022(20010405):4<370:ACSUIM>2.0.ZU;2-S
Abstract
We synthesized new DNA intercalators, polyol- or cyclic sugar-linked anthra quinone derivatives. The binding affinity of these DNA intercalators is sug gested to be controlled by the configuration and steric structure of sugar chain with the cyclic sugar chain interacting more strongly than the open-c hain polyol unit with double stranded DNA.